This webinar explores the application of a Target-Mediated Drug Disposition (TMDD) model to characterize the pharmacokinetics of warfarin, a widely used anticoagulant with complex and highly variable behavior. Presenter Shen Cheng provides an overview of warfarin’s pharmacology, the influence of CYP2C9 genetic variants on drug exposure, and the limitations of traditional linear compartment models in capturing its prolonged terminal half-life. The session introduces the TMDD framework as a mechanistic approach to better represent warfarin’s saturable tissue binding and nonlinear disposition. A central focus of the webinar is the practical implementation and translation of the TMDD model from NONMEM to Phoenix NLME, including comparisons of coding structure, parameterization, and model outputs. Through demonstration and discussion, attendees gain insight into model-building workflows, software-specific considerations, and best practices for pharmacometric analysis using TMDD methods.