Webinar Overview (Part 1 of 2024 Webinar Series)
Webinar Overview (Part 1 of 2024 Webinar Series)
This webinar is the first in a four-part series recorded in 2024, in which the authors extend the concepts from the widely used textbook PK/PD Data Analysis: Concepts and Applications (5th Edition) toward material planned for a future 6th Edition. While the book focuses primarily on individual (naïve pooled) analyses, this webinar series introduces population-based approaches using non-linear mixed-effects (NLME) modeling.
The authors present the PK52 case study from the book, illustrating the use of population modeling to analyze pharmacokinetic data. The example examines a short half-life, renally eliminated antioxidant studied in normal and renal-clamped rats, highlighting the concept of effective half-life. The analysis supports the design of a first-in-human constant-infusion PK study.
In this webinar, the authors demonstrate how to:
Simulate population-level datasets from published mean PK data in both rat groups
Introduce realistic assumptions for within-subject and between-subject variability
Fit the same structural PK model using population (NLME) methods rather than individual analyses
Use population modeling results to better support translational PK understanding and study design
This session provides a practical introduction to population analysis and sets the foundation for subsequent webinars in the series.