Webinar Overview (PD Series – Part 4, 2025)
Webinar Overview (PD Series – Part 4, 2025)
This webinar is the fourth installment in the 2025 Pharmacodynamics (PD) Series presented by the authors. Using a real-world case study, it illustrates key concepts in pharmacodynamic inter-species scaling and translational modeling from preclinical to clinical development.
Key topics include:
Application of allometric approaches to scale pharmacodynamic potency (IC₅₀)
Use of in vivo rat biomarker data to inform human dose predictions for Phase I studies
Interpretation of Phase I clinical data demonstrating age-related slowing of target turnover in humans, a phenomenon not observed in rats
Approaches to selecting the most effective dose in Phase II studies while accounting for age-dependent pharmacodynamic differences