Webinar Overview (PD Series – Part 3, 2025)
Webinar Overview (PD Series – Part 3, 2025)
Inter-species scaling of PD Models: New expression of in vivo potency
This webinar introduces a redefined model for In Vivo Potency, moving beyond standard in vitro binding to account for physiological variables.
Potency is now characterized by the interaction of three specific rates:
Binding Kinetics: The kon and koff rates.
Target Turnover kdeg: The natural degradation rate of the physiological target.
Irreversible Complex Loss koff, RC: The rate at which the drug-target complex is permanently removed from the system.